Van de Ven Double Ends Everton's Run at New Stadium
The Dutch defender became the first backline player to net two goals in a Premier League game for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven nods into the net twice in first half
Everton's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets third in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs prolonged their winning streak on the road in the top division and handed Everton their first defeat at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left their historic home behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the opening 45 minutes to put their impressive record at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - nodded in a final goal to seal the victory.
The Everton defender believed he had levelled the scores a short while after Van de Ven's first goal, directing a bullet header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a succession of fine stops to guarantee the London club went five away games without defeat in the English top flight.
But the VAR stepped in, advising Craig Pawson to review the goal on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win elevates the manager's team up to third in the division, five points off local foes and leaders Arsenal.
The Merseyside club remain in 14th position and sit half a dozen points clear of the relegation zone.
Tottenham analysis: Van de Ven excels in duties at each end of the field
Following a uninspiring weekday display in the Champions League against the French side, where they mustered a only attempts on goal, the manager opted for the French striker up front instead of former Toffees player the Brazilian.
The summer signing was unable to make much of an impact before being substituted for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the final outcome.
Defender the Dutchman transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the six-yard box for an free Van de Ven to head home.
And Ven de Ven - filling in as skipper in Cristian Romero's unavailability - notched his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was equally outstanding in defensive duties, combining well with Kevin Danso as the pair dealt superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Toffees missing finishing touch
Everton's new home had been a fortress, but it appears the freshness may have worn off slightly and fans headed to the gates after the midfielder's third for Tottenham.
The break in Everton's unbeaten home run will not be a massive concern for David Moyes, but their striker situation will be.
Beto and the other striker - the Everton's two established centre-forwards - had scored just one league goal between them before Sunday's outing.
And they were failed to contribute to that miserable record on a wet and gloomy night on in Liverpool.
The striker's form was summed up when he chose to overhead kick a golden opportunity from near the goal, despite having space and opportunity to reposition for a simpler shot that would have tested Vicario.
Barry, too, failed to influence the game after replacing the starter in the second half.
It was not for a shortage of chance. The majority of Everton's attacks came through Grealish and the forward, who relentlessly delivered dangerous crosses into the Tottenham penalty area.
What next for these two sides?
Everton: Moyes' men head to the Stadium of Light in the Premier League on early November at 8 PM.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against the Magpies.